Pyrazinamide

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Pyrazinamide Prescription Drug Information

Pyrazinamide (By mouth)
Pyrazinamide (pir-a-ZIN-a-mide)

Treats tuberculosis (TB), usually in combination with other TB drugs.

Brand Name(s):
There may be other brand names for Pyrazinamide.

When Pyrazinamide Should Not Be Used:
You should not use Pyrazinamide if you have had an allergic reaction to pyrazinamide, ethionamide, isoniazid (INH) or niacin (nicotinic acid, Nicobid®).

How to Use Pyrazinamide:
Tablet

• Your doctor will tell you how much to take and how often.
• Take Pyrazinamide exactly as your doctor ordered. You must take Pyrazinamide for as long as your doctor ordered. Even if you feel better, do not stop taking Pyrazinamide.
• May be taken with or without food or milk.

If a dose of Pyrazinamide is missed:

• Take the missed dose as soon as you remember.
• Skip the missed dose if it is almost time for your next regular dose.
• You should not use two doses at the same time.

How to Store and Dispose of Pyrazinamide:

• Store at room temperature, away from heat, moisture, and direct light.
• Keep all medicine out of the reach of children.

Drugs and Foods to Avoid While Taking Pyrazinamide:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using Pyrazinamide:

• Check with your doctor before taking Pyrazinamide if you have diabetes, gout or liver disease.
• Talk with your doctor before taking Pyrazinamide if you are pregnant or breastfeeding.

Possible Side Effects While Using Pyrazinamide:
Call your doctor right away if you notice any of these side effects:

• Skin rash, severe itching or hives
• Pain or swelling in the joints
• Yellowing of the skin or eyes
• Fever or chills
• Dark urine

If you notice these less serious side effects while taking Pyrazinamide, talk with your doctor:

• Nausea or vomiting
• Unusual tiredness or loss of appetite

If you notice other side effects that you think are caused by Pyrazinamide, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088